Enza Torino
University of Naples Federico II, Italy
Title: Hydrodenticity to enhance relaxivity of MRI contrast agents
Biography
Biography: Enza Torino
Abstract
Recently, rational design of a new class of contrast agents (CAs), based on biopolymers, have received considerable attention in Magnetic Resonance Imaging (MRI) at diagnostic field. Several strategies have been adopted to improve relaxivity without chemical modification of the commercial CAs, however, understanding the MRI enhancement mechanism remains a challenge. A multidisciplinary approach is used to highlight the basic principles ruling biopolymer-CA interactions in the perspective of their influence on the relaxometric properties of the CA. The study of polymer-CA solutions reveals that thermodynamic interactions between biopolymers and CAs could be used to improve MRI Gdbased CA efficiency. Several techniques can be used to obtain nanoparticles.. The effect of the hydration of the hydrogel structure on the relaxometric properties, called hydrodenticity and its application to the nanomedicine field, is exploited.The explanation of this concept takes place through several key aspects underlying biopolymer-CAs interactions mediated by the water. In addition, hydrodenticity is applied to develop gadolinium-based polymer nanovectors with size around 200 nm with improved MRI relaxation time (10-times). The experimental results indicate that the entrapment of metal chelates in hydrogel nanostructures offers a versatile platform for developing different high performing CAs for disease diagnosis